教師基本信息
姓名：楊青
職稱：教授
電子郵箱：yangqing68@fudan.edu.cn
辦公地點：万博体育分
辦公電話：021-31246641
個人網頁/課題組主頁：
研究方向
利用生物化學、藥物化學、分子藥理學等手段，進行疾病發生的分子機製研究及相關藥物的研發。重點研究：①IDO（吲哚胺-2,3雙加氧酶）催化的色氨酸代謝通路失調與疾病的關係，篩選發現幹預IDO及相應的信號傳導的抑製劑；②Drug Transporter (藥物轉運蛋白) 在藥物代謝中的功能及其表達、定位的調控機製研究。
個人簡介
楊青，女，博士，万博英超狼队网官方网 教授。中國藥理學會抗炎免疫藥理專業委員會委員，上海市藥學會理事，上海市藥學會生化藥物專業委員會副主任委員。上海市浦江人才。
2000年畢業於北海道大學生物有機化學專業，獲博士學位。2001至2003年於北海道大學和岐阜大學進行博士後研究，2004-2006年任東京大學藥學部JSPS外國人研究員。2006年回國，先後任狗万外围充值 藥學院、万博体育分 副教授，2011年任博士生導師，2012年任教授。先後主持“重大慢性非傳染性疾病防控研究專項” 科技重大專項課題，“重大新藥創製”科技重大專項課題，國家自然科學基金麵上項目，上海市浦江人才計劃，上海市生物醫藥重點課題，教育部博導基金，教育部留學回國人員基金等課題。
先後獲得中國藥學會科學技術獎（2017年，三等；2012年，三等）、上海藥學科技獎（2016年，一等；2011年度，三等）、複星醫藥獎教金（2011年、2012年）、陸宗霖獎教金（2017年）、中國僑界貢獻獎（創新人才，2016年）、2016中國科學年度新聞人物候選人、中國技術市場協會金橋獎（2020年，項目二等）。
授課情況
講授上海市精品課程《生物化學》（上、下）
招生專業
生物藥物學
代表性論文和論著
1. Yu Yao#, Heng Liang#, Xin Fang, Shengnan Zhang, Zikang Xing, Lei Shi, Chunxiang Kuang, Barbara Seliger, Qing Yang*. What is the prospect of indoleamine 2,3-dioxygenase 1 inhibition in cancer? Extrapolation from the past. Journal of Experimental & Clinical Cancer Research, 2021, 40: 60
2. Weirui Li, Leilei Guo, Zikang Xing, Xin Fang, Heng Liang, Shengnan Zhang, Lei Shi, Chunxiang Kuang, Leming Shi, Yuanting Zheng*, Yueqing Hu*, Qing Yang*. 43 key gene expressions involved in the effect of indoleamine 2,3-dioxygenase 1 (IDO1) expression on cancer prognosis may be a potential IDO1 inhibitor biomarker. Clinical and Translational Medicine, 2021;11:e330
3.Shengnan Zhang, Leilei Guo, Dan Yang, Zikang Xing, Weirui Li, Chunxiang Kuang, Qing Yang*. Evaluation and Comparison of the Commonly Used Bioassays of Human Indoleamine 2,3-dioxygenase 1(IDO1) and Tryptophan 2,3- dioxygenase (TDO) Bioorganic Chemistry, Volume 104, 2020, 104348
4. Zhenzhen Duan, Shengnan Zhang, Heng Liang, Zikang Xing, Leilei Guo, Lei Shi, Lisha Du, Chunxiang Kuang, Osamu Takikawa, Qing Yang*. Amyloid β neurotoxicity is IDO1-Kyn-AhR dependent and blocked by IDO1 inhibitor. Signal Transduction and Targeted Therapy, 2020, 5: 96.
5. Lisha Du, Zikang Xing, Bangbao Tao, Tianqi Li, Dan Yang, Weirui Li, Yuanting Zheng, Chunxiang Kuang, Qing Yang*. Both IDO1 and TDO contribute to the malignancy of gliomas via Kyn-AhR-AQP4 signal pathway. Signal Transduction and Targeted Therapy. 2020, 5:10
6. Dan Yang, Shengnan Zhang, Xin Fang, Leilei Guo, Nan Hu, Zhanling Guo, Xishuai Li, Shuangshuang Yang, Jin Chao He, Chunxiang Kuang* andQing Yang* N-benzyl/aryl substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2, 3-Dioxygenase and Tryptophan 2, 3-dioxygenase. J. Med. Chem.2019,62 (20), 9161-9174.
7. Dan Yang, Tianqi Li, Yinlong Li, Shengnan Zhang, Weirui Li, Heng Liang, Zikang Xing, Lisha Du, Jinchao He, Chunxiang Kuang, Qing Yang*, H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 2019, 38:88.
8. Heng Liang, Mantian Chen, Fangfei Qi, Lei Shi, Zhenzhen Duan, Ruoyu Yang, Jinchao He, Bin Lou, Yigang Li*, Qing Yang*.The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis. Signal Transduction and Targeted Therapy, 2019, 4:23.
9. Shengnan Zhang, Fangfei Qi, Xin Fang, Dan Yang, Hairong Hu, Qiang Huang, Chunxiang Kuang, Qing Yang*, Tryptophan 2,3-dioxygenase Inhibitory Activities of Tryptanthrin Derivatives. Eur J Med Chem. 2018,160, 133-145.
10. Yang Li, Nan Hu, Dan Yang, Gregory Oxenkrug, Qing Yang*, Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism, FEBS J., 2017, 284, 948-966.
11. Juanjuan Li, Yang Li, Dan Yang, Nan Hu, Zhanling Guo, Chunxiang Kuang and Qing Yang*, Establishment of a human indoleamine 2, 3-dioxygenase2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016, 123:171-179.
12.Guiying Jin, Yang Li, Yuwen Zhu, Lisha Du, Junkai Yan and Qing Yang*, SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells. Cell Biology and Toxicology, 2016, 32(6):483-497.
13.Yu D#, Tao BB#, Yang YY, Du LS, Yang SS, He XJ, Zhu YW, Yan JK, Yang Q*. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis,2015, 43(1):291-302.
14.Junkai Yan, Guiying Jin, Lisha Du, and Qing Yang*. Modulation of intestinal folate absorption by erythropoietin in vitro. Mol. Pharmaceutics, 2014, 11(1), 358-366.
15. Yang, Shuangshuang, Li, Xishuai, Hu, Fangfang, Li, Yinlong, Yang, Yunyun, Yan, Junkai, Kuang, Chunxiang, Yang, Qing*, Discovery of Tryptanthrin Derivatives as Potent Inhibitors of Indoleamine 2, 3-Dioxygenase with Therapeutic Activity in LLC tumor-bearing Mice.J. Med. Chem.2013, 56 (21),8321–8331.
16.Xiao-Jie He, Wei-Rong Wang, Yun Zhang, Qing Yang*. The Effect of Radixin Knockdown on the Expression and Efflux Function of MRP2 in SGC-7901 Cells. Eur. J. Pharm. Sci, 2012, 46,426-434.
17. Qiang Huang, Maofa Zheng, Shuangshuang Yang, Chunxiang Kuang, Cunjing Yu, Qing Yang*, Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1, 2, 3-triazoles as indoleamine 2, 3-dioxygenase (IDO) inhibitors. Eur. J. Med. Chem, 2011, 46(11), 5680-5687.
18.Yu Zhang, Jibin Dong, Xingang Zhu, Weirong Wang, Qing Yang*. The Effect of Sphingomyelin Synthase 2 (SMS2) Deficiency on the Expression of Drug Transporters in Mouse Brain. Biochem.Pharmacol, 2011, 82, 287–294.
19. CunJing Yu, MaoFa Zheng, ChunXiang Kuang, WeiDa Huang, Qing Yang*. Oren-gedoku-to and its constituents with therapeutic potential of Alzheimer′s disease inhibit indoleamine 2, 3-dioxygenase activity in vitro. J Alzheimers Dis, 2010, 22 (1), 257-266.
20. 張勝男,劉鑫, 楊青*. 吲哚胺2,3-雙加氧酶1及其抑製劑的研究, 複旦學報(醫學版), 2017, 44(1), 1-7.
21. 孔令雷, 匡春香, 楊青*, IDO抑製劑的研究進展. 中國藥物化學雜誌. 2009, 19,147-154.
22. 楊青等。一種N-苄基色胺酮衍生物及其製備方法和應用（PCT專利）。已獲得中國、美國、歐洲、日本、澳洲、南非、香港等國家和地區授權。