教師基本信息：
職稱：副教授Associate Professor
電子郵箱：xhhu@fudan.edu.cn
辦公地點：生科院大樓G623 Life Science Building G623
研究方向：
利用分子遺傳學、細胞生物學、小鼠動物模型、生物信息學等手段，研究肺癌及腦腫瘤發生發展的分子機製。主要研究方向:（1）基於新一代測序的組學數據，尋找和發掘導致肺癌和腦腫瘤的驅動基因，並致力於揭示其分子機理；（2）解析變異蛋白異常相分離驅動腫瘤發生的機製及篩選相關抗腫瘤小分子藥。
We use molecular genetics, cell biology, mouse animal models, bioinformatics and other methods to uncover the molecular mechanics of the occurrence and development of lung cancer and brain tumors. Main research directions: (1) Identify the driver genes that induce lung cancer and brain tumors, and reveal their molecular mechanisms underlying tumorigenesis based on next-generation sequencing omics data; (2) Dissect the mechanism of abnormal phase separation of mutant proteins to drive tumorigenesis and screen related anti-tumor small molecule drugs.
個人簡介：
博士，副教授。2006年獲狗万外围充值 遺傳學博士。2006年-2010年，狗万外围充值 生物醫學研究院助理研究員。2011-至今，狗万外围充值 生命學院副教授。2018年-2020年，美國辛辛那提兒童醫院醫學中心訪問科學家。連續多年擔任國家基金委青年基金、麵上項目的通訊評審專家；教育部研究生論文抽查評審專家、研究生論文校際評審專家。
Ph.D. in Genetics from Fudan University in 2006. Research assistant at the Institutes of Biomedical Sciences, Fudan University from 2006-2010. Associate professor at the School of Life Sciences, Fudan University since 2011. Visiting scientist at Cincinnati Children’s Hospital Medical Center from 2018 to 2020. Communication review expert for the Youth Fund and General Projects of the National Foundation of China; an expert of the Ministry of Education for spot check review of postgraduate thesis and an expert for inter-school review of postgraduate thesis.
通識核心課程“身邊的基因科學”和通識課程“生命的科學”
General Core Curriculum “Gene Sciences in Daily Life”and General Curriculum “Sciences of Life”
招生專業：
腫瘤遺傳學腫瘤（Tumor Genetics）、生物信息學 (Bioinformatics)、生物與醫藥 (Biology and medicine)
科研項目：
(1) 基於多層次組學數據遺傳分析的肺癌轉移和複發分子遺傳機製的解析，國家自然科學基金麵上項目，2019-01 至 2022-12，57萬元，主持
(2) 一種酵母新型RNA轉錄幹擾機製研究，國家自然科學基金麵上項目，2016-01 至 2019-12，60萬元，主持
(3) 一種新型酵母細胞粘附變異的遺傳解析及分子機製，國家自然科學基金麵上項目，2013-01 至 2016-12，70萬元，主持
(4) 基於新一代測序數據的統計遺傳學新理論、方法與應用，國家973計劃項目，2012-01 至 2016-08，300萬元，子課題負責人
(1) NSFC General Program:
Title: Uncovering the genetic mechanism underlying metastasis and relapse of lung cancer through genetic analysis of multi-level omic sequencing data
Sponsor: National Natural Science Foundation of China
Funding: CNY 570,000.00
Role: Principle Investigator
Period of Protocol: Jan. 2019 – Dec. 2022
(2) NSFC General Program:
Title: Unveiling a novel mechanism underlying transcriptional interference in Saccharomyces cerevisiae
Sponsor: National Natural Science Foundation of China
Funding: CNY 600,000.00
Role: Principle Investigator
Period of Protocol: Jan. 2016 – Dec. 2019
(3) NSFC General Program:
Title: Genetic dissection and molecular mechanisms of a novel type of yeast cell adhesion
Sponsor: National Natural Science Foundation of China
Funding: CNY 700,000.00
Role: Principle Investigator
Period of Protocol: Jan. 2013 – Dec. 2016
(4) Basic Science Research Program of China:
Title: Developing novel theoretical methodology and application based on next-generation sequencing data in statistical genetics (My role: To obtain four high-quality omic-sequencing datasets (RNA-seq, miRNA-seq, methylation-seq and exon-seq) of clinical specimens and cell lines of non-small cell lung cancer)
Funding: CNY 8,360,000.00
Role: Co-PI
Period of Protocol: Jan. 2012 – Aug. 2016
獲獎情況：
複星醫藥獎教金（2016），生命學院優秀教師（2013，2014）
Fosun medical scholarship (2016)，Outstanding teacher of the School of Life Sciences (2013,2014)
代表性論文和論著：
X Hu, X Wu, et al. (2023) Nuclear condensates of YAP fusion proteins alter transcription to drive ependymoma tumorigenesis. Nature Cell Biology, 25:323-336.
Pu W, …, Hu X, et al. (2021) Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma. Nature Communications 12: 6058.
X Pan*, XH Hu*, et al. (2019). Identification of the copy number variant biomarkers for breast cancer subtypes. Molecular Genetics and Genomics 294 (1), 95-110.
T Liu, X Wu, T Chen, Z Luo, X Hu. (2018). Downregulation of DNMT3A by miR-708-5p inhibits lung cancer stem cell-like phenotypes through repressing Wnt/β-catenin signaling. Clin Cancer Res 24 (7), 1748-1760.
Chen L*, Pan X*, Hu X*, Zhang YH, Wang S, Huang T, Cai YD. (2018). Gene expression differences among different MSI statuses in colorectal cancer. International Journal of Cancer. 143 (7), 1731-1740.
O Fang*, X Hu*, et al. (2018). Amn1 governs post-mitotic cell separation in Saccharomyces cerevisiae. PLoS genetics 14 (10), e1007691.
X Wu, T Liu, O Fang, LJ Leach，X Hu#, Z Luo#. (2014) miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1. Oncogene 33(12):1506-1514.
L Wang, N Jiang, L Wang, O Fang, Lindsey J. Leach, X Hu#, Z Luo#. (2014) 3’ Untranslated Regions Mediate Transcriptional Interference Between Convergent Genes Both Locally and Ectopically in Saccharomyces cerevisiae. PloS Genetics 10(1): e1004021.