姓名：服部素之/ Motoyuki HATTORI
職稱：研究員/Professor
職務：研究員/Professor
電子郵箱：hattorim@fudan.edu.cn
辦公地點：上海市楊浦區淞滬路2005號万博体育分 A201
研究方向
離子通道以及轉運體的結構與功能，膜蛋白的表達鑒定技術研發，蛋白質從頭設計。
個人簡介
教育工作經曆
2005年獲得日本東京大學生物化學學士學位，2009年獲得日本東京工業大學生命信息博士學位。2009-2012年在美國俄勒岡健康與科學大學從事博士後研究，2012-2015年在日本東京大學生物化學係任助理研究員及JST研究員。
科研項目
國家自然科學基金麵上項目和外青項目、外國優秀青年項目、國際合作交流項目、科技部重點研發計劃青年科學家專題等。
授課情況
分子生物學課程，結構生物學課程，現代生物化學和結構生物學訓練課程
招生專業
生理和生物物理/Physiology and Biophysics
代表性論文和論著：
1. Jin F, Lin YY, Wang RC, Xie TX, Zhao Y, Shen C, Sheng D, Ichikawa M, Yu Y, Wang J*, Hattori M*. Cryo-EM structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily. Proc Natl Acad Sci U S A. 2024, 121(44):e2405659121.
2. Sumino A, Sumikama T, Zhao Y, Flechsig H, Umeda K, Kodera N, Konno H, Hattori M*, Shibata M*. High-Speed Atomic Force Microscopy Reveals Fluctuations and Dimer Splitting of the N-Terminal Domain of GluA2 Ionotropic Glutamate Receptor-Auxiliary Subunit Complex. ACS Nano. 2024, 18(36):25018-25035.
3. Sheng D, Yue CX, Jin F, Wang Y, Ichikawa M, Yu Y, Guo CR*, Hattori M*. Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists. eLife. 2024, 12:RP92829.
4. Shen C, Zhang Y, Cui W, Zhao Y, Sheng D, Teng X, Shao M, Ichikawa M, Wang J*, Hattori M*. Structural insights into the allosteric inhibition of P2X4 receptors. Nat Commun. 2023, 14(1):6437.
5. Sumino A*, Zhao Y, Mukai D, Sumikama T, Puppulin L, Hattori M*, Shibata M. Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel. Proc Natl Acad Sci U S A. 2023, 120(20):e2301013120.
6. Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M*. The structure of MgtE in the absence of magnesium provides new insights into channel gating. PLoS Biol. 2021, 19(4):e3001231.
7. Huang Y, Jin F, Funato Y, Xu Z, Zhu W, Wang J, Sun M, Zhao Y, Yu Y, Miki H*, Hattori M*. Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter. Sci Adv. 2021, 7(7):eabe6140.
8. Jia Y, Zhao Y, Kusakizako T, Wang Y, Pan C, Zhang Y, Nureki O*, Hattori M*, Yan Z*. TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels. Neuron. 2020, 105(2):310-321.
9. Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gomez J*, Hattori M*, Swartz K*. Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. eLife. 2019, 8:e47060.
10. Wang J, Wang Y, Cui WW, Huang Y, Yang Y, Liu Y, Zhao WS, Cheng XY, Sun WS, Cao P, Zhu MX, Wang R*, Hattori M*, Yu Y*. Druggable negative allosteric site of P2X3 receptors. Proc Natl Acad Sci U S A. 2018, 115(19):4939-4944.