教師基本信息
職稱：教授
電子郵箱：huiru_tang（at）fudan.edu.cn (at means @)
辦公地點：複旦生科院D105室
辦公電話：021-31246725
狗万外围充值 特聘教授、國家傑出青年科學基金獲得者、英國皇家化學會會士、國家重點研發計劃項目首席。1986年獲西北輕工業學院（現陝西科技大學）學士、1994年獲倫敦大學博士學位。1992-2005年先後在英國BBSRC食品研究所、帝國理工學院生物醫學部任Senior Scientist等職。2005-2014年先後任中科院武漢物數所研究員、博導、研究部副主任、中科院生物磁共振分析重點實驗室創建主任。2014年加盟万博英超狼队网官方网 。曾任英國NHS、科技部973及蛋白質重大計劃等評審專家、J Proteome Res編委。發表Nature、Nat Microbiol、Nat Aging、Cell Rep、Cell Rep Med、Immunity、PNAS、EMBO J、J Hepatol、JACS及Anal Chem等SCI論文220餘篇，被引1.5萬餘次（H指數~70）；有國內外發明專利10餘項。部分工作被Science、Nature等作為“研究亮點”專文評述。
現任中國生物物理學會代謝組學分會會長；中國抗癌協會腫瘤代謝分會、中國生物化學與分子生物學會脂質與脂蛋白委員會、中國營養學會基礎營養分會、中國生物物理學會自由基生物學及醫學分會等常務理事，國際實驗磁共振大會（ENC）執委（大中華地區唯一）；Metabolomics、Arch Pharm和《基礎醫學與臨床》等編委，Nutrition & Metabolism及Phenomics等副主編。
Personal website: http://www.metabolome.cn/
主要研究方向 (Research Interests)
定量代謝組學技術及引用，包括定量代謝組學與脂質組學新技術體係、重要疾病發生發展和有效幹預的代謝組機製、宿主代謝與腸道菌群相互作用機製與健康。聚焦代謝物功能及代謝組學30餘年，發展了高通量超靈敏代謝組學、代謝組與轉錄組/蛋白質組/微生物組數據整合分析等技術，研究重大疾病發生發展及有效幹預的分子基礎。曾主持國家傑出青年科學基金、國家重點研發計劃、國家自然科學基金重大、973課題等項目多項。現承擔國家重點研發計劃、國家創新群體、上海市級重大專項等任務。
榮譽及獲獎情況 (Awards)
英國皇家化學會會士（2005）、國家傑出青年科學基金（2008）、新世紀百千萬人才工程國家級人選稱號（2009）、王天眷波譜學獎（2010）、武漢市優秀科技工作者（2011）、“精準醫學研究”國家重點研發計劃項目首席（2017-2020）、“生物前沿技術”國家重點研發計劃項目首席（2022-2027）。
代表性通訊作者論文（含共通訊; 一區）
1. Q. Huang, et al, “A metabolome-derived score predicts metabolic dysfunction-associated steatohepatitis and mortality from liver disease”, J Hepatol,82:781-793, 2025
2. H. Wang, et al, “Simultaneous profiling of multiple phosphorylated metabolites in typical biological matrices via ion-pair reversed-phase ultrahigh-performance liquid chromatography and mass spectrometry”, Anal Chem, 97:1681–1687, 2025.
3. Y. Sun, et al, “Simultaneous quantification of carboxylate enantiomers in multiple human matrices with the hydrazide-assisted ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry”, Anal Chem, 96:18141-18149 2024.
4. J. Xiao, et al, “25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages”, Immunity, 57:1087–1104, 2024
5. Z.L. Wang, et al, “Total synthesis of all stereoisomers of C5-glyceryl-methyl-20-deoxycytidine 5gmC and their occurrence in Chlamydomonas reinhardtii”, Cell Rep Phys Sci, 5:102041, 2024
6. Y.N. Pu, et al, “Gut microbial features and circulating metabolomic signatures of frailty in older adults”, Nat Aging, 4:1249-1262,2004
7. Q.S. Chen, et al, “A novel endogenous retention-index for minimizing retention-time variations in metabolomic analysis with reversed-phase ultrahigh-performance liquid-chromatography and mass spectrometry”, Talanta, 268:125318, 2024.
8. J.X. Zhang, et al, “Simultaneously quantifying hundreds of acylcarnitines in multiple biological matrices within ten minutes using ultrahigh-performance liquid-chromatography and tandem mass spectrometry”, J Pharm Anal, 14:140-148, 2024.
9. C.C. Zhang, et al, “Detecting sub-micromolar analytes in mixtures with a 5-min acquisition on 600 MHz NMR spectrometers”, J Am Chem Soc, 145:25513–25517, 2023
10. Y.B. Feng, et al, “Anopheline mosquitoes are protected against parasite infection by tryptophan catabolism in gut microbiota”, Nat Microbiol, 7:707-715, 2022.
11. Z.M. Hou, et al, “Inhibiting 3bHSD1 to eliminate the oncogenic effects of progesterone in prostate cancer”, Cell Rep Med, 3:100561, 2022.
12. J.H. Liu, et al, “Simultaneous quantification of 70 elements in biofluids within 5 min using inductively coupled plasma mass spectrometry to reveal elementomic phenotypes of healthy Chinese adults”, Talanta, 238:123720, 2022
13. M. F. Xia, et al, “Insights into contribution of genetic variants towards the susceptibility of MAFLD revealed by the NMR_based lipoprotein profiling”, J Hepatol, 74:974-977, 2021.
14. Y. Xu, et al, “Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues”, EMBO J. e108069, 2021.\
15. M.F. Wang, et al, “Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH”, Cell Rep, 35:108992, 2021
16. J.H. Xue, et al, “A vitamin-C-derived DNA modification catalysed by an algal TET homologue”, Nature, 569:581–585, 2019.
17. H. Lin, et al, “Alterations of bile acids and gut microbiota in obesity induced by high fat diet in rat model”, J Agric Food Chem, 67:3624-3632. 2019.【高被引, 年均被引>30次】
18. Q.F. Wan, et al, Quantitative 13C traces of glucose fate in hepatitis B virus infected hepatocytes, Anal Chem, 89:3293–3299, 2017
19. L. Sun, et al, cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. Cell Res, 25:429–444, 2015.
20. M. Li, et al, “Human symbiotic gut microbes specifically modulate metabolic phenotypes”, PNAS, 105:2117-2122, 2008.【高被引, 年均被引>50次】
論文及引用Publication List publons.com/researcher/2776607/huiru-tang/
www.researchgate.net/profile/Huiru-Tang/research