教師基本信息
職稱：研究員
電子郵箱：chend@fudan.edu.cn
辦公地點：万博英超狼队网官方网 E301-2
辦公電話：021-31246742
個人簡介（工作經曆）
狗万外围充值 特聘教授、万博英超狼队网官方网 教授、遺傳工程國家重點實驗室PI、狗万外围充值 附屬中山醫院雙聘教授，博士生導師。2008年畢業於中國科學技術大學，細胞生物學博士；畢業後赴美國貝勒醫學院從事生物質譜和蛋白質組學博士後研究工作；2012年全職回國在北京蛋白質組研究中心任副研究員、研究員；2015年加入万博英超狼队网官方网 。目前擔任狗万外围充值 科技期刊發展中心主任，狗万外围充值 人類表型組研究院副院長，中國生物物理學會表型組學分會創會秘書長，Springer出版集團《Phenomics》雜誌創刊執行主編、國家十四五重點研發計劃“生物大分子與微生物”首席科學家；入選國家級人才計劃，北京市“海聚工程”特聘教授，北京市“優秀青年人才”，上海市“曙光人才計劃”，上海市“優秀學術帶頭人計劃”。近5年以通訊作者在Nat Biotechnol（2篇）、Nat Nanotechnol、Nat Biomed Eng、Cell Research、Gastroenterology、J Hematol Oncol（3篇）、Sci Transl Med、Nature Commun（21篇）、Cell Discov（2篇）、Adv Sci、Sci Adv、Hepatology、Genome Biol、Mol Cell、EMBO J、PNAS等國際高水平雜誌發表論文70餘篇，受邀撰寫綜述2篇，被引4000餘次。主持國家科技部重點研發計劃課題2項、科技部國際合作項目1項、863課題1項、國家自然科學基金重點項目3項、北京市自然科學基金1項、北京市留學人員重點項目1項，上海市市級重大科技專項1項，上海市張江專項2項，產學研項目1項；獲得中國專利11項、美國專利1項。
研究方向
主要從事以蛋白質組為核心的臨床多組學研究
Ø 開發一站式高效蛋白質組技術係統和數據雲平台Firmiana。
Ø 建立了內源性轉錄因子活性分析技術（catTFRE）、轉錄因子DNA修飾結合偏好性解析技術（modi-TFRE）、染色質開放域轉錄調控蛋白質機器解析技術（ATAC-MS）。
Ø 利用多維度組學解析了腦部腫瘤（膠質瘤、垂體瘤、脊索瘤），消化道腫瘤（食管癌、胃癌、胃腸間質瘤、壺腹部腫瘤、胰腺癌、膽管癌、結直腸癌、結直腸早癌、十二指腸早癌），泌尿係統腫瘤（腎癌、膀胱癌），17個器官鱗癌，軟組織肉瘤，黑色素瘤，乳腺癌各進展階段，肺癌各進展階段等多個世界或中國首項腫瘤人群多組學圖譜，建立了完善的樣本檢測、數據處理、整合分析與可視化流程，明確了不同腫瘤的跨組學分子調控網絡和腫瘤特異性驅動通路。
核心技術
Ø 一站式高效蛋白質組技術係統和數據雲平台Firmiana（Nat Biotechnol，2017，2023）
Ø 內源性轉錄因子活性分析技術（catTFRE）（Nature Commun，2018，2019，2020）（發明專利3項）
Ø 轉錄因子DNA修飾結合偏好性解析技術（modi-TFRE）（Adv Sci，2021）
Ø 染色質開放域轉錄調控蛋白質機器解析技術（ATAC-MS）（Sci Adv，2021）
Ø 細胞和區域分辨率蛋白質組學解析技術（Cell Reports，2023）
招生專業
生物化學與分子生物學
獲獎情況
2013年北京市第九批“海聚工程”
2014年北京市第七批“優秀青年人才”
2019年上海市“曙光人才”
2022年上海市“優秀學科帶頭人”
2022年國家級人才計劃
2024年兩項研究工作入選“中國2023年度重要醫學進展”
代表性論文和論著
1. Zhang Q, Xu X, Jiang D, Wang Y, Wang H, Zhu J, Tang S, Wang R, Zhao S, Li K, Feng J, Xiang H, Yao Z, Xu N, Fang R, Guo W, Liu Y*, Hou Y*, Ding C*. Integrated proteogenomic characterization of ampullary adenocarcinoma. Cell Discov. 2025 Jan 7;11(1):2. doi: 10.1038/s41421-024-00742-4. PMID: 39762212; PMCID: PMC11704194.（Cell Discovery, IF=13.0）
2. Ran P, Wang Y, Li K, He S, Tan S, Lv J, Zhu J, Tang S, Feng J, Qin Z, Li Y, Huang L, Yin Y, Zhu L, Yang W*, Ding C*. STAVER: a standardized benchmark dataset-based algorithm for effective variation reduction in large-scale DIA-MS data. Brief Bioinform. 2024 Sep 23;25(6):bbae553. doi: 10.1093/bib/bbae553. PMID: 39504480; PMCID: PMC11540132.（Briefings In Bioinformatics, IF=6.8）
3. Xu G, Yu J, Lyu J, Zhan M, Xu J, Huang M, Zhao R, Li Y, Zhu J, Feng J, Tan S, Ran P, Su Z, Liu X, Zhao J, Zhang H*, Xu C*, Chang J*, Hou Y*, Ding C*. Proteogenomic Landscape of Breast Ductal Carcinoma Reveals Tumor Progression Characteristics and Therapeutic Targets. Adv Sci (Weinh). 2024 Oct 17:e2401041. doi: 10.1002/advs.202401041. Epub ahead of print. PMID: 39418072.（Advanced Science, IF=14.3）
4. Zhang Q, Xu Z, Han R, Wang Y, Ye Z, Zhu J, Cai Y, Zhang F, Zhao J, Yao B, Qin Z, Qiao N, Huang R, Feng J, Wang Y, Rui W, He F*, Zhao Y*, Ding C*. Proteogenomic characterization of skull-base chordoma. Nat Commun. 2024 Sep 27;15(1):8338. doi: 10.1038/s41467-024-52285-7. PMID: 39333076; PMCID: PMC11436687.（Nature Communication, IF=14.7）
5. Xiang H, Luo R, Wang Y, Yang B, Xu S, Huang W, Tang S, Fang R, Chen L, Zhu N, Yu Z, Akesu S, Wei C, Xu C*, Zhou Y*, Gu J*, Zhao J*, Hou Y*, Ding C*. Proteogenomic insights into the biology and treatment of pan-melanoma. Cell Discov. 2024 Jul 23;10(1):78. doi: 10.1038/s41421-024-00688-7. PMID: 39039072; PMCID: PMC11263678.（Cell Discovery, IF=13）
6. Li L, Jiang D, Liu H, Guo C, Zhang Q, Li X, Chen X, Chen Z, Feng J, Tan S, Huang W, Huang J, Xu C*, Liu CY*, Yu W*, Hou Y*, Ding C*. Comprehensive Proteogenomic Profiling Reveals the Molecular Characteristics of Colorectal Cancer at Distinct Stages of Progression. Cancer Res. 2024 Jun 11. doi: 10.1158/0008-5472.CAN-23-1878. Epub ahead of print. PMID: 38861363.（Cancer Research, IF=12.5）
7. Lyu J, Bai L, Li Y, Wang X, Xu Z, Ji T, Yang H, Song Z, Wang Z, Shang Y, Ren L, Li Y, Zang A, Jia Y*, Ding C*. Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy. Nat Commun. 2024 May 8;15(1):3860. doi: 10.1038/s41467-024-47835-y. PMID: 38719824.（Nature Communication, IF=14.7）
8. Zhang P, Zhang W, Wang X, Li L, Lin Y, Wu N, Mao R, Lin J, Kang M*, Ding C*. BCLAF1 drives esophageal squamous cell carcinoma progression through regulation of YTHDF2-dependent SIX1 mRNA degradation. Cancer Lett. 2024 Apr 16;591:216874. doi: 10.1016/j.canlet.2024.216874. Epub ahead of print. PMID: 38636894.（Cancer Letters, IF=9.1）
9. Ma F, Li Y, Xiang C, Wang B, Lv J, Wei J, Qin Z, Pu Y, Li K, Teng H, Tan S, Feng J, Shang Z, Wang Y, Tian S, Du C*, Han Y*, Ding C*. Proteomic characterization of esophageal squamous cell carcinoma response to immunotherapy reveals potential therapeutic strategy and predictive biomarkers. J Hematol Oncol. 2024 Mar 15;17(1):11. doi: 10.1186/s13045-024-01534-9. PMID: 38491392; PMCID: PMC10943778.（Journal of Hematology & Oncology, IF=29.5）
10. Sun M, Tong Y, Yuan W, Wang Y, Pu Y, Huang W, Lv B, Xu C, Jiang W, Luo R, Fang R, Tang S, Ren L, Wang J, Feng J, Sun C, Shen K*, He F*, Hou Y*, Ding C*. Proteomic Characterization Identifies Clinically Relevant Subgroups of Gastrointestinal Stromal Tumors. Gastroenterology. 2024 Mar;166(3):450-465.e33. doi: 10.1053/j.gastro.2023.11.284. Epub 2023 Nov 22. PMID: 37995868.（Gastroenterology, IF=25.7）
11. Tang S, Wang Y, Luo R, Fang R, Liu Y, Xiang H, Ran P, Tong Y, Sun M, Tan S, Huang W, Huang J, Lv J, Xu N, Yao Z, Zhang Q, Xu Z, Yue X, Yu Z, Akesu S, Ding Y, Xu C*, Lu W*, Zhou Y*, Hou Y*, Ding C*. Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma. Nat Commun. 2024 Feb 15;15(1):1381. doi: 10.1038/s41467-024-45306-y. PMID: 38360860; PMCID: PMC10869728.（Nature Communication, IF=14.7）
12. Li Y, Wang B, Yang W, Ma F, Zou J, Li K, Tan S, Feng J, Wang Y, Qin Z, Chen Z*, Ding C*. Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer. Nat Commun. 2024 Feb 1;15(1):980. doi: 10.1038/s41467-024-44911-1. PMID: 38302471; PMCID: PMC10834432.（Nature Communication, IF=14.7）
13. Li Y, Wang B, Ma F, Jiang D, Wang Y, Li K, Tan S, Feng J, Wang Y, Qin Z, Xu G, Tian S, Zhang X, Xu C*, Wu J*, Xu J*, Hou Y*, Ding C*. Proteomic characterization of the colorectal cancer response to chemoradiation and targeted therapies reveals potential therapeutic strategies. Cell Rep Med. 2023 Dec 19;4(12):101311. doi: 10.1016/j.xcrm.2023.101311. Epub 2023 Dec 11. PMID: 38086380; PMCID: PMC10772406.（Cell Reports Medicine, IF=11.7）
14. Qu Y, Yao Z, Xu N, Shi G, Su J, Ye S, Chang K, Li K, Wang Y, Tan S, Pei X, Chen Y, Qin Z, Feng J, Lv J, Zhu J, Ma F, Tang S, Xu W, Tian X, Anwaier A, Tian S, Xu W, Wu X, Zhu S, Zhu Y, Cao D, Sun M, Gan H, Zhao J*, Zhang H*, Ye D*, Ding C*. Plasma proteomic profiling discovers molecular features associated with upper tract urothelial carcinoma. Cell Rep Med. 2023 Sep 19;4(9):101166. doi: 10.1016/j.xcrm.2023.101166. Epub 2023 Aug 25. PMID: 37633276; PMCID: PMC10518597.（Cell Reports Medicine, IF=11.7）
15. Yao Z, Xu N, Shang G, Wang H, Tao H, Wang Y, Qin Z, Tan S, Feng J, Zhu J, Ma F, Tian S, Zhang Q, Qu Y, Hou J*, Guo J*, Zhao J*, Hou Y*, Ding C*. Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ. Nat Commun. 2023 Sep 13;14(1):5670. doi: 10.1038/s41467-023-41139-3. PMID: 37704624; PMCID: PMC10499981.（Nature Communication, IF=14.7）
16. Zheng Y, Liu Y, Yang J, Dong L, Zhang R, Tian S, Yu Y, Ren L, Hou W, Zhu F, Mai Y, Han J, Zhang L, Jiang H, Lin L, Lou J, Li R, Lin J, Liu H, Kong Z, Wang D, Dai F, Bao D, Cao Z, Chen Q, Chen Q, Chen X, Gao Y, Jiang H, Li B, Li B, Li J, Liu R, Qing T, Shang E, Shang J, Sun S, Wang H, Wang X, Zhang N, Zhang P, Zhang R, Zhu S, Scherer A, Wang J, Wang J, Huo Y, Liu G, Cao C, Shao L, Xu J, Hong H, Xiao W, Liang X, Lu D, Jin L, Tong W, Ding C*, Li J*, Fang X*, Shi L*. Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials. Nat Biotechnol. 2024 Jul;42(7):1133-1149. doi: 10.1038/s41587-023-01934-1. Epub 2023 Sep 7. PMID: 37679543; PMCID: PMC11252085.（Nature Biotechnology, IF=33.1）
17. Tian S, Zhan D, Yu Y, Wang Y, Liu M, Tan S, Li Y, Song L, Qin Z, Li X, Liu Y, Li Y, Ji S, Wang S; Proteomic Massive Analysis and Quality Control Consortium; Zheng Y*, He F*, Qin J*, Ding C*. Quartet protein reference materials and datasets for multi-platform assessment of label-free proteomics. Genome Biol. 2023 Sep 7;24(1):202. doi: 10.1186/s13059-023-03048-y. PMID: 37674236; PMCID: PMC10483797.（Genome Biology, IF=10.1）
18. Wang L, Wan F, Xu Y, Xie S, Zhao T, Zhang F, Yang H, Zhu J, Gao J, Shi X, Wang C, Lu L, Yang Y, Yu X, Chen S, Sun X, Ding J, Chen P*, Ding C*, Xu F*, Yu H*, Peng H*. Hierarchical helical carbon nanotube fibre as a bone-integrating anterior cruciate ligament replacement. Nat Nanotechnol. 2023 Sep;18(9):1085-1093. doi: 10.1038/s41565-023-01394-3. Epub 2023 May 4. PMID: 37142709.（Nature Nanotechnology, IF=38.1）
19. Zhang H, Bai L, Wu XQ, Tian X, Feng J, Wu X, Shi GH, Pei X, Lyu J, Yang G, Liu Y, Xu W, Anwaier A, Zhu Y, Cao DL, Xu F, Wang Y, Gan HL, Sun MH, Zhao JY*, Qu Y*, Ye D*, Ding C*. Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor. Nat Commun. 2023 Jul 17;14(1):4274. doi: 10.1038/s41467-023-39981-6. PMID: 37460463; PMCID: PMC10352361.（Nature Communication, IF=14.7）
20. Zhuang A, Zhuang A, Chen Y, Qin Z, Zhu D, Ren L, Wei Y, Zhou P, Yue X, He F*, Xu J*, Ding C*. Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes. Elife. 2023 May 9;12:e82959. doi: 10.7554/eLife.82959. PMID: 37158593; PMCID: PMC10234629.（Elife, IF=6.4）
21. Li L, Jiang D, Liu H, Guo C, Zhao R, Zhang Q, Xu C, Qin Z, Feng J, Liu Y, Wang H, Chen W, Zhang X, Li B, Bai L, Tian S, Tan S, Yu Z, Chen L, Huang J, Zhao JY*, Hou Y*, Ding C*. Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes. Nat Commun. 2023 Mar 29;14(1):1751. doi: 10.1038/s41467-023-37221-5. PMID: 36991000; PMCID: PMC10060430.（Nature Communication, IF=14.7）
22. Li L, Jiang D, Zhang Q, Liu H, Xu F, Guo C, Qin Z, Wang H, Feng J, Liu Y, Chen W, Zhang X, Bai L, Tian S, Tan S, Xu C, Song Q, Liu Y, Zhong Y, Chen T, Zhou P*, Zhao JY*, Hou Y*, Ding C*. Integrative proteogenomic characterization of early esophageal cancer. Nat Commun. 2023 Mar 25;14(1):1666. doi: 10.1038/s41467-023-37440-w. PMID: 36966136; PMCID: PMC10039899.（Nature Communication, IF=14.7）
23. Xiang H, Zhang B, Wang Y, Xu N, Zhang F, Luo R, Ji M*, Ding C*. Region-resolved multi-omics of the mouse eye. Cell Rep. 2023 Feb 28;42(2):112121. doi: 10.1016/j.celrep.2023.112121. Epub 2023 Feb 14. PMID: 36790928.（Cell Reports, IF=7.5）
24. Shi W, Wang Y, Xu C, Li Y, Ge S, Bai B, Zhang K, Wang Y, Zheng N, Wang J, Wang S, Ji G, Li J, Nie Y, Liang W, Wu X, Cui J, Wang Y, Chen L*, Zhao Q*, Shen L*, He F*, Qin J*, Ding C*. Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer. Nat Commun. 2023 Feb 14;14(1):835. doi: 10.1038/s41467-023-35797-6. PMID: 36788224; PMCID: PMC9929250.（Nature Communication, IF=14.7）
25. Deng M, Ran P, Chen L, Wang Y, Yu Z, Cai K, Feng J, Qin Z, Yin Y, Tan S, Liu Y, Xu C*, Shi G*, Ji Y*, Zhao JY*, Zhou J*, Fan J*, Hou Y*, Ding C*. Proteogenomic characterization of cholangiocarcinoma. Hepatology. 2023 Feb 1;77(2):411-429. doi: 10.1002/hep.32624. Epub 2022 Jul 5. PMID: 35716043; PMCID: PMC9869950.（Hepatology, IF=12.9）
26. Wang Y, Luo R, Zhang X, Xiang H, Yang B, Feng J, Deng M, Ran P, Sujie A, Zhang F, Zhu J, Tan S, Xie T, Chen P, Yu Z, Li Y, Jiang D, Zhang X*, Zhao JY*, Hou Y*, Ding C*. Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms. Nat Commun. 2023 Jan 31;14(1):505. doi: 10.1038/s41467-023-36005-1. PMID: 36720864; PMCID: PMC9889805.（Nature Communication, IF=14.7）
27. Qu Y, Wu X, Anwaier A, Feng J, Xu W, Pei X, Zhu Y, Liu Y, Bai L, Yang G, Tian X, Su J, Shi GH, Cao DL, Xu F, Wang Y, Gan HL, Ni S, Sun MH, Zhao JY*, Zhang H*, Ye D*, Ding C*. Proteogenomic characterization of MiT family translocation renal cell carcinoma. Nat Commun. 2022 Dec 5;13(1):7494. doi: 10.1038/s41467-022-34460-w. PMID: 36470859; PMCID: PMC9722939.（Nature Communication, IF=14.7）
28. Zhang F, Zhang Q*, Zhu J, Yao B, Ma C, Qiao N, He S, Ye Z, Wang Y, Han R, Feng J, Wang Y, Qin Z, Ma Z, Li K, Zhang Y, Tian S, Chen Z, Tan S, Wu Y, Ran P, Wang Y, Ding C*, Zhao Y*. Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors. Cell Res. 2022 Dec;32(12):1047-1067. doi: 10.1038/s41422-022-00736-5. Epub 2022 Oct 28. PMID: 36307579; PMCID: PMC9715725.（Cell Research, IF=28.2）
29. Qie J, Liu Y, Wang Y, Zhang F, Qin Z, Tian S, Liu M, Li K, Shi W, Song L, Sun M, Tong Y, Hu P, Gong T, Wang X, Huang Y, Lin B, Zheng X, Zhou R, Lv J, Du C, Wang Y, Qin J, Yang W*, He F*, Ding C*. Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues. Nat Commun. 2022 Nov 30;13(1):7389. doi: 10.1038/s41467-022-35095-7. PMID: 36450731; PMCID: PMC9712610.（Nature Communication, IF=14.7）
30. Tong Y, Sun M, Chen L, Wang Y, Li Y, Li L, Zhang X, Cai Y, Qie J, Pang Y, Xu Z, Zhao J, Zhang X, Liu Y, Tian S, Qin Z, Feng J, Zhang F, Zhu J, Xu Y, Lou W, Ji Y, Zhao J, He F*, Hou Y*, Ding C*. Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma. J Hematol Oncol. 2022 Nov 25;15(1):168. doi: 10.1186/s13045-022-01384-3. PMID: 36434634; PMCID: PMC9701038.（Journal of Hematology & Oncology, IF=29.5）
31. Li Y, Xu C, Wang B, Xu F, Ma F, Qu Y, Jiang D, Li K, Feng J, Tian S, Wu X, Wang Y, Liu Y, Qin Z, Liu Y, Qin J, Song Q, Zhang X, Sujie A, Huang J, Liu T*, Shen K*, Zhao JY*, Hou Y*, Ding C*. Proteomic characterization of gastric cancer response to chemotherapy and targeted therapy reveals potential therapeutic strategies. Nat Commun. 2022 Nov 8;13(1):6749. doi: 10.1038/s41467-022-34238-0. Erratum for: Nat Commun. 2022 Sep 29;13(1):5723. PMID: 36347856; PMCID: PMC9643381.（Nature Communication, IF=14.7）
32. Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z, Zhu J, Zhang F, Feng J, Tian S, Liu Y, Zhao J, Hou J, Guo J*, Hou Y*, Ding C*. Integrated proteogenomic characterization of urothelial carcinoma of the bladder. J Hematol Oncol. 2022 Jun 3;15(1):76. doi: 10.1186/s13045-022-01291-7. PMID: 35659036; PMCID: PMC9164575.（Journal of Hematology & Oncology, IF=29.5）
33. Qu Y, Feng J, Wu X, Bai L, Xu W, Zhu L, Liu Y, Xu F, Zhang X, Yang G, Lv J, Chen X, Shi GH, Wang HK, Cao DL, Xiang H, Li L, Tan S, Gan HL, Sun MH, Qiu J, Zhang H*, Zhao JY*, Ye D*, Ding C*. A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population. Nat Commun. 2022 Apr 19;13(1):2052. doi: 10.1038/s41467-022-29577-x. PMID: 35440542; PMCID: PMC9019091.（Nature Communication, IF=14.7）
34. Zhang H, Qin Z, Yue X, Liu Y, Sun X, Feng J, Xu Z, Zhao J, Li K, Qiu J, Yang W*, He F*, Ding C*. Proteome-wide profiling of transcriptional machinery on accessible chromatin with biotinylated transposons. Sci Adv. 2021 Oct 22;7(43):eabh1022. doi: 10.1126/sciadv.abh1022. Epub 2021 Oct 22. PMID: 34678055.（Science Advances, IF=11.7）
35. Bai L, Yang G, Qin Z, Lyu J, Wang Y, Feng J, Liu M, Gong T, Li X, Li Z, Li J, Qin J, Yang W*, Ding C*. Proteome-Wide Profiling of Readers for DNA Modification. Adv Sci (Weinh). 2021 Oct;8(19):e2101426. doi: 10.1002/advs.202101426. Epub 2021 Aug 5. PMID: 34351703; PMCID: PMC8498917.（Advanced Science, IF=14.3）
36. Wang Y, Song L, Liu M, Ge R, Zhou Q, Liu W, Li R, Qie J, Zhen B, Wang Y, He F*, Qin J*, Ding C*. A proteomics landscape of circadian clock in mouse liver. Nat Commun. 2018 Apr 19;9(1):1553. doi: 10.1038/s41467-018-03898-2. PMID: 29674717; PMCID: PMC5908788.（Nature Communication, IF=14.7）
37. Feng J, Ding C*, Qiu N, Ni X, Zhan D, Liu W, Xia X, Li P, Lu B, Zhao Q, Nie P, Song L, Zhou Q, Lai M, Guo G, Zhu W, Ren J, Shi T*, Qin J*. Firmiana: towards a one-stop proteomic cloud platform for data processing and analysis. Nat Biotechnol. 2017 May 9;35(5):409-412. doi: 10.1038/nbt.3825. PMID: 28486446.（Nature Biotechnology, IF=33.1）