鄭丙蓮

發布時間：2021-07-09瀏覽次數：12702

教師基本信息

姓名：鄭丙蓮

職稱：教授（Professor），博士生導師

電子郵箱：zhengbl@fudan.edu.cn

辦公地點：江灣校區生科樓C401-405（Room C405, Building of Life Sciences, Jiangwan campus）


招生專業：生化係-表觀遺傳學（Biochemistry-Epigenetics）


研究方向

非編碼RNA與植物生殖發育

非編碼RNA基於其種類繁多、數量巨大、功能多樣等特征而被譽為生命科學研究中的“暗物質”。我們以擬南芥和入侵植物為研究對象，探索不同種類的非編碼RNA，主要關注小RNA、套索RNA、轉座子RNA，如何產生、如何發揮作用以及在植物生殖細胞命運決定和環境可塑性發育中發揮何種作用。我們近年的研究成果揭示了小RNA產生和效應複合體新的轉錄後調控機製、揭示了植物精細胞攜帶的特定非編碼RNA促進種子早期細胞分裂、開發了RNA剪切反應中內含子形成的套索RNA的鑒定方法和功能研究體係、開辟了內含子套索RNA代謝調控和功能研究的新方向。在Dev Cell, PNAS, Plant Cell, PLoS Genet, Nat Commun, New Phytol等期刊以通訊作者身份發表多篇研究論文。目前實驗室的研究工作主要集中於套索RNA和轉座子RNA的代謝調控和生物學功能。

RNA biology in plants

Non-coding RNAs ubiquitously exist in plants and animals, which are involved various biological processes at the transcriptional and posttranscriptional levels. Our research uses Arabidopsis as the model system and focuses on non-coding RNAs， especially small RNA, lariat RNAs, TE RNA. We have been focused on how plant cells produce non-coding RNAs, how non-coding RNAs act in gene silencing, and what the biological consequences of non-coding RNAs during plant gametogenesis and early seed development. In my opinion, the most striking finding in my lab is that by developing a systemic method to identify lariat RNAs, traditionally as the “by-products” of RNA splicing, we demonstrate that lariat RNAs can be selectively retained to regulate various biological processes in a spatiotemporally regulated manner. Another interesting finding in my lab is that sperm-delivered miRNA triggers the first endosperm nuclear division event. Future work will focus on the mechanism of lariat RNA turnover, biological significance of lariat RNA accumulation, and roles of non-coding RNA-mediated epigenetic regulation in gamete cell fate determination and genome integrity in plants. We hope that studies in my lab about these fundamental mechanisms in plant epigenetics will help people understanding species biodiversity and evolution.


教育工作經曆

1994-2001華中師範大學生科院，學士、碩士

2001-2006中科院遺傳與發育生物學研究所，博士

2006-2012美國加州大學河濱分校、伯克利分校，博士後

2012-今狗万外围充值 生科院，教授、博導

1994-2001 Central China Normal University, Bachelor and Master

2001-2006 Institute of Genetics and Developmental Biology, CAS, Ph.D

2006-2012 University of California-Riverside and -Berkeley, Postdoc,

2012-present Fudan University, Professor


學術兼職

JIPB、Seed Biol、Front Plant Sci、植物學報的Editor；中國細胞學會植物細胞分會副理事長、中國植物生理學會常務理事、中國生物化學學會RNA專業委員會委員、上海植物生理學會秘書長、中國植物女科學家分會委員、中國植物青年科學家分會委員等

Editor, Journal of Integrative Plant Biology、Seed Biology、Frontiers in Plant Science

Associate Editor, Frontiers in Plant Science

Committee, Chinese Society for Plant Biology

Committee, Chinese Society for RNA Biology


在研項目

主持國家自然科學基金傑出青年基金、重點項目、中德合作交流基金項目；科技部重大研發計劃子課題等

National Natural Science Foundation of China, Jiechu Qingnian Grant, Zhongdian Grant, Youxiu Qingnian Grant, Mobility Programme of Sino-German Center


獲獎情況

曾獲中國植物生理學會衛誌明青年創新獎、全國生命科學創新創業大賽指導教師一等獎、狗万外围充值 巾幗英雄創新獎、狗万外围充值 三八紅旗手等

Wei Zhiming Award of Chinese Society for Plant Biology, FOSUN medical Prize


授課情況

講授本科生榮譽課程《表觀遺傳學》、《生命科學研究與設計》;本科生專業進階課程《植物發育生物學》、《RNA生物學》、《發育生物學》、

Epigenetics, Advanced Interdisciplinary Biology Seminars, Plant Developmental Biology, Developmental Biology, RNA Biology


代表性論文（#共同第一作者，*通訊作者）：

  1. Zhang Z, Zhang X, Tang Q, Li L, Jiang J, Fang Y, Zhang H, Zhai J, Ren G, Zheng B* (2023).A repertoire of intronic lariat RNAs reveals tissue-specific regulation and target mimicry potential in plants.Sci China Life Sci, in press.

  2. Jiang T, Zheng B* (2022). Epigenetic regulation of megaspore mother cell formation.Front Plant Sci, 12: 826871.

  3. Wang T, Zheng Y, Tang Q, Zhong S, Su W, Zheng B* (2021). Brassinosteroids inhibit miRNA-mediated translational repression by decreasing AGO1 on the endoplasmic reticulum.J Integr Plant Biol, 8: 1475-1590.

  4. Wang T, Zhang X, Zheng B* (2021). Identification of intronic lariat-derived circular RNAs in Arabidopsis by RNA deep sequencing. Method Mol Biol, 2362: 93-100.

  5. Zhao Y, Jiang T, Li L, Zhang X, Yang T, Liu C, Chu J, Zheng B* (2021).The chromatin remodeling complex ISWI controls stamen filament elongation by promoting JA biosynthesis in Arabidopsis. J Genet Genomics,48: 123-133.

  6. Wu W, Li L, Zhao Y, Zhao YS, Jiang T, McCormick S, Zheng B* (2021). Heterochromatic silencing mediated by ARID1 small RNA movement in Arabidopsis. New Phytol, 229: 3269-3280.

  7. Zhang X#, Zhang Y#,Wang T, Li Z, Cheng J, GeH, Tang Q, Chen K, Liu L, Lu C, Guo J, Zheng B*, Zheng Y*(2019). A comprehensive map of intron branchpoints and lariat RNAs in plants. Plant Cell, 31: 956-973.

  8. Zhong S, Xu Y, Yu C, Zhang X, Ren G, Wang Y, Ma J, Zheng Y, Zheng B* (2019). Anaphase Promoting Complex/Cyclosome regulates RdDM activity by degrading DMS3 in Arabidopsis.PNAS, 116: 3899-3908.

  9. Wu W, Zheng B* (2019). Intercellular delivery of small RNAs in plant gametes. New Phytol, 224:86-90.

  10. Zhao Y#, Wang S#, Wu W, Li L, Jiang T, Zheng B* (2018). Clearance of maternal barriers by paternal miR159 to initiate endosperm nuclear divisions in Arabidopsis.Nat Commun,9: 5011.

  11. Su C, Li Z, Cheng J, Li L, Zhong S, Liu L, Zheng Y., Zheng B* (2017). The protein phosphatase 4 and SMEK1 complex dephosphorylates HYL1 to promote miRNA biogenesis by antagonizing the MAPK cascade in Arabidopsis.Dev Cell, 41: 527-539.

  12. Li Z#, Wang S#, Cheng J, Su C, Zhong S, Liu Q, Fang Y, Yu Y, Lv H, Zheng Y*, and Zheng B* (2016). Intron lariat RNA inhibits microRNA biogenesis by sequestering the dicing complex in Arabidopsis.PLoS Genet,e1006422.



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